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Anti-Inflammatory and Anti-Vascular Leakage Effects by Combination of < em > Centella asiatica < /em > and < em > Vitis vinifera < /em > L. Leaf Extracts
Evid Based Complement Alternat Med. 2021 Apr 14;2021:7381620. doi: 10.1155/2021/7381620. eCollection 2021.ABSTRACTVenous insufficiency results from several factors responsible for the progression of inflammation and oxidative damage of veins. Recently, natural extracts have been proposed for the treatment of venous insufficiency, but their efficacies have not been fully elucidated. In the present study, we evaluate the combinatorial effects on anti-inflammatory and anti-vascular leakage potential of mixed compositions containing different proportions of Centella asiatica extract (CE) and Vitis vinifera L. leaf extract (VVE...
Source: Evidence-based Complementary and Alternative Medicine - May 3, 2021 Category: Complementary Medicine Authors: Myung-Gi Seo Min-Jeong Jo Nam In Hong Min Jung Kim Kyu Suk Shim Eunju Shin Jeong Jun Lee Sang-Joon Park Source Type: research

Tumor vascular disrupting agent DMXAA inhibits platelet activation and thrombosis via inhibition of TXA2 signaling and phosphodiesterase.
CONCLUSIONS: For the first time, we found that tumor-vascular disrupting agent, DMXAA has potent antiplatelet and antithrombotic effects without any bleeding diathesis. As DMXAA inhibits platelet activity with safe profile, DMXAA could be used as an efficacious and safe antiplatelet drug. This article is protected by copyright. All rights reserved. PMID: 23902231 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 1, 2013 Category: Hematology Authors: Zhang SH, Zhang Y, Shen J, Zhang S, Chen L, Gu J, Mruk JS, Cheng G, Zhu L, Kunapuli SP, Ding Z Tags: J Thromb Haemost Source Type: research

Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of Maerua angolensis DC (Capparaceae) in Murine.
Authors: Ampadu FA, Boakye-Gyasi E, Osafo N, Benneh CK, Ekuadzi E, Woode E Abstract Maerua angolensis has been used traditionally in the management of pain, arthritis, and rheumatism in Ghana and Nigeria but no scientific evidence is currently available to give credence to its folkloric use. The aim of this study was therefore to evaluate the anti-inflammatory effects of a stem bark extract of Maerua angolensis DC (MAE) in acute inflammatory models. The effects of MAE (30-300 mg kg-1) on neutrophil infiltration, exudate volume, and endogenous antioxidant enzymes in lung tissues and lung morphology were evaluated wi...
Source: International Journal of Inflammation - August 17, 2018 Category: Allergy & Immunology Tags: Int J Inflam Source Type: research

Tumor vascular disrupting agent DMXAA inhibits platelet activation and thrombosis via inhibition of TXA2 signaling and phosphodiesterase
ConclusionsFor the first time, we found that tumor‐vascular disrupting agent, DMXAA has potent antiplatelet and antithrombotic effects without any bleeding diathesis. As DMXAA inhibits platelet activity with safe profile, DMXAA could be used as an efficacious and safe antiplatelet drug.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - August 1, 2013 Category: Hematology Authors: S.H. Zhang, Y. Zhang, J. Shen, S. Zhang, L. Chen, J. Gu, J.S. Mruk, G. Cheng, L. Zhu, S.P. Kunapuli, Z. Ding Tags: Original Article Platelets Source Type: research

Tumor vascular disrupting agent 5,6‐dimethylxanthenone‐4‐acetic acid inhibits platelet activation and thrombosis via inhibition of thromboxane A2 signaling and phosphodiesterase
ConclusionsFor the first time, we found that tumor vascular disrupting agent DMXAA has potent antiplatelet and antithrombotic effects without any bleeding diathesis. As DMXAA inhibits platelet activity with safe profile, DMXAA could be used as an efficacious and safe antiplatelet drug.
Source: Journal of Thrombosis and Haemostasis - October 10, 2013 Category: Hematology Authors: S. H. Zhang, Y. Zhang, J. Shen, S. Zhang, L. Chen, J. Gu, J.S. Mruk, G. Cheng, L. Zhu, S. P. Kunapuli, Z. Ding Tags: Original Article Source Type: research

Lysosomal exocytosis of ATP is coupled to P2Y2 receptor in marginal cells in the stria vascular in neonatal rats.
Abstract Adenosine triphosphate (ATP) is stored as lysosomal vesicles in marginal cells of the stria vascular in neonatal rats, but the mechanisms of ATP release are unclear. Primary cultures of marginal cells from 1-day-old Sprague-Dawley rats were established. P2Y2 receptor and inositol 1,4,5-trisphosphate (IP3) receptor were immunolabelled in marginal cells of the stria vascular. We found that 30 μM ATP and 30 μM uridine triphosphate (UTP) evoked comparable significant increases in the intracellular Ca2+ concentration ([Ca2+]i) in the absence of extracellular Ca2+, whereas the response was suppressed by 1...
Source: Cell Calcium - September 21, 2018 Category: Cytology Authors: Liu B, Cao W, Li J, Liu J Tags: Cell Calcium Source Type: research

Evaluation of Antimicrobial Activity of Four Organic Acids Used in Chicks Feed to Control Salmonella typhimurium: Suggestion of Amendment in the Search Standard.
Authors: El Baaboua A, El Maadoudi M, Bouyahya A, Belmehdi O, Kounnoun A, Zahli R, Abrini J Abstract Today, the general public has become increasingly aware of salmonellosis problems. Organic acids are known by their antimicrobial potential and commonly used for improving the quality of poultry feed. In this context, the present work evaluated the inhibitory effect of four organic acids, namely, acetic acid, citric acid, lactic acid, and tartaric acid, at different levels of contamination by Salmonella typhimurium. The neutralization of these organic acids in vitro and in the presence of one-day-old chick's organs ...
Source: International Journal of Microbiology - October 28, 2018 Category: Microbiology Tags: Int J Microbiol Source Type: research

Induction of hypoxia by vascular disrupting agents and the significance for their combination with radiation therapy.
Conclusions. VDAs clearly induced tumour hypoxia. This had the potential to decrease the efficacy of radiation. However, if the appropriate timing and scheduling were used an enhanced effect was observed using both single and fractionated radiation treatments. PMID: 23988183 [PubMed - as supplied by publisher]
Source: Acta Oncologica - August 29, 2013 Category: Cancer & Oncology Authors: Iversen AB, Busk M, Horsman MR Tags: Acta Oncol Source Type: research

Treatment with a vascular disrupting agent does not increase recruitment of indium labelled human endothelial outgrowth cells in an experimental tumour model
Conclusion: Our data showed that regardless of the grade of the immune system, ranging from a fully working to a fully compromised immune system, treatment with CA4P did not increase recruitment of xenotransplanted EOCs to tumour tissue.
Source: BMC Cancer - December 2, 2014 Category: Cancer & Oncology Authors: Lotte BertelsenAnja BohnYuan ShenLise FalborgHans Stødkilde-JørgensenMichael Horsman Source Type: research

Cystatin C, vascular biomarkers and measured glomerular filtration rate in patients with unresponsive hypertensive phenotype: a pilot study.
CONCLUSION: In addition to GFR, cystatin C serum concentration is positively and independently associated with CCIMT in patient with URHT phenotype and subclinical CVD. Prospective larger studies should further investigate the clinical importance of this relationship. PMID: 27876431 [PubMed - as supplied by publisher]
Source: Renal Failure - November 25, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

An Intelligent Vascular Disrupting Dendritic Nanodevice Incorporating Copper Sulfide Nanoparticles for Immune Modulation ‐Mediated Combination Tumor Therapy
An intelligent dendritic nanodevice incorporated with both copper sulfide nanoparticles and 5,6-dimethylxanthenone-4-acetic acid within the dendrimer internal cavities and surface modified with a targeting agent LyP-1 peptide is developed for immune modulation-mediated combination tumor therapy, simultaneously inhibiting primary tumor growth and tumor metastasis through enhanced photothermal therapy and disruption of both tumor blood vessels and lymphatic vessels. AbstractDevelopment of intelligent nanoplatforms that can simultaneously target multiple factors associated with tumor growth and metastasis remains an extreme c...
Source: Small - June 1, 2023 Category: Nanotechnology Authors: Yiming Zhang, Zhijun Ouyang, Mengsi Zhan, Rui Yang, Yue Gao, Lulu Li, Rui Guo, Xiangyang Shi, Xueyan Cao Tags: Research Article Source Type: research

Vascular priming enhances chemotherapeutic efficacy against head and neck cancer
Conclusion: Our results show that preconditioning of the tumor microenvironment with an antivascular agent primes the tumor vasculature and results in enhancement of chemotherapeutic delivery and efficacy in vivo. Further investigation into the activity of antivascular agents in combination with chemotherapy against HNSCC is warranted.
Source: Oral Oncology - July 25, 2013 Category: Cancer & Oncology Authors: Margaret Folaron, James Kalmuk, Jaimee Lockwood, Costakis Frangou, Jordan Vokes, Steven G. Turowski, Mihai Merzianu, Nestor R. Rigual, Maureen Sullivan-Nasca, Moni A. Kuriakose, Wesley L. Hicks, Anurag K. Singh, Mukund Seshadri Tags: Featured Article Source Type: research